| Indole-3-carbaldehyde (I3A), also known as indole-3-aldehyde and 3-formylindole, is a metabolite of dietary L-tryptophan which is synthesized by human gastrointestinal bacteria, particularly species of the Lactobacillus genus. I3A is a biologically active metabolite which acts as a receptor agonist at the aryl hydrocarbon receptor in intestinal immune cells, in turn stimulating the production of interleukin-22 which facilitates mucosal reactivity. |
|
Read full article at Wikipedia
|
InChI=1S/C13H16N2O2/c1- 9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) |
| DRLFMBDRBRZALE-UHFFFAOYSA-N |
| C=1C=C(C=C2C(=CNC12)CCNC(=O)C)OC |
|
|
Mus musculus
(NCBI:txid10090)
|
Source: BioModels - MODEL1507180067
See:
PubMed
|
|
Homo sapiens
(NCBI:txid9606)
|
See:
DOI
|
|
radical scavenger
A role played by a substance that can react readily with, and thereby eliminate, radicals.
|
|
|
hormone
Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
immunological adjuvant
A substance that augments, stimulates, activates, potentiates, or modulates the immune response at either the cellular or humoral level. A classical agent (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contains bacterial antigens. It could also be endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Its mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy is related to its antigen-specific immunoadjuvanticity.
human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
mouse metabolite
Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
|
|
|
anticonvulsant
A drug used to prevent seizures or reduce their severity.
central nervous system depressant
A loosely defined group of drugs that tend to reduce the activity of the central nervous system.
immunological adjuvant
A substance that augments, stimulates, activates, potentiates, or modulates the immune response at either the cellular or humoral level. A classical agent (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contains bacterial antigens. It could also be endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Its mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy is related to its antigen-specific immunoadjuvanticity.
geroprotector
Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
|
|
View more via ChEBI Ontology
|
N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
|
|
5-methoxy-N-acetyltryptamine
|
ChemIDplus
|
|
Melatonin
|
KEGG COMPOUND
|
|
melatonin
|
UniProt
|
mélatonine
|
ChEBI
|
|
N-[2-(5-methoxyindol-3-yl)ethyl]acetamide
|
NIST Chemistry WebBook
|
|
N-Acetyl-5-methoxytryptamine
|
KEGG COMPOUND
|
|
205542
|
Reaxys Registry Number
|
Reaxys
|
|
73-31-4
|
CAS Registry Number
|
ChemIDplus
|
|
73-31-4
|
CAS Registry Number
|
NIST Chemistry WebBook
|
|
