nitric oxide (CHEBI:16480)

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ChEBI Name	nitric oxide

ChEBI ID	CHEBI:16480

Definition	A nitrogen oxide which is a free radical, each molecule of which consists of one nitrogen and one oxygen atom.

Stars	This entity has been manually annotated by the ChEBI Team.

Secondary ChEBI IDs	CHEBI:14657, CHEBI:44452, CHEBI:25546, CHEBI:7583

Supplier Information	ChemicalBook:CB8112259, eMolecules:478458, ZINC000004474696

Download	Molfile XML SDF

Wikipedia	License
Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega−6 fatty acid 20:4(ω−6), or 20:4(5,8,11,14). If its precursors or diet contains linoleic acid it is formed by biosynthesis and can be deposited in animal fats. It is a precursor in the formation of leukotrienes, prostaglandins, and thromboxanes. Together with omega−3 fatty acids and other omega−6 fatty acids, arachidonic acid provides energy for body functions, contributes to cell membrane structure, and participates in the synthesis of eicosanoids, which have numerous roles in physiology as signaling molecules. Its name derives from the ancient Greek neologism arachis 'peanut', although peanut oil does not contain any arachidonic acid. Arachidonate is the name of the derived carboxylate anion (conjugate base of the acid), salts, and some esters.
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Formula

Net Charge

Average Mass

30.00614

Monoisotopic Mass

29.99799

InChI

InChI=1S/NO/c1-2

InChIKey

MWUXSHHQAYIFBG-UHFFFAOYSA-N

SMILES

[N]=O

Metabolite of Species	Details
Mus musculus (NCBI:txid10090)	Source: BioModels - MODEL1507180067 See: PubMed
Escherichia coli (NCBI:txid562)	See: PubMed
Homo sapiens (NCBI:txid9606)	See: DOI

Roles Classification
Chemical Role(s):	radical scavenger A role played by a substance that can react readily with, and thereby eliminate, radicals.

Biological Role(s):	Escherichia coli metabolite Any bacterial metabolite produced during a metabolic reaction in Escherichia coli. human metabolite Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). neurotransmitter An endogenous compound that is used to transmit information across the synapse between a neuron and another cell. signalling molecule A molecular messenger in which the molecule is specifically involved in transmitting information between cells. Such molecules are released from the cell sending the signal, cross over the gap between cells by diffusion, and interact with specific receptors in another cell, triggering a response in that cell by activating a series of enzyme controlled reactions which lead to changes inside the cell. mouse metabolite Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).

Application(s):	bronchodilator agent An agent that causes an increase in the expansion of a bronchus or bronchial tubes. vasodilator agent A drug used to cause dilation of the blood vessels.

ChEBI Ontology
Outgoing	nitric oxide (CHEBI:16480) has role Escherichia coli metabolite (CHEBI:76971) nitric oxide (CHEBI:16480) has role bronchodilator agent (CHEBI:35523) nitric oxide (CHEBI:16480) has role human metabolite (CHEBI:77746) nitric oxide (CHEBI:16480) has role mouse metabolite (CHEBI:75771) nitric oxide (CHEBI:16480) has role neurotransmitter (CHEBI:25512) nitric oxide (CHEBI:16480) has role radical scavenger (CHEBI:48578) nitric oxide (CHEBI:16480) has role signalling molecule (CHEBI:62488) nitric oxide (CHEBI:16480) has role vasodilator agent (CHEBI:35620) nitric oxide (CHEBI:16480) is a inorganic radical (CHEBI:36871) nitric oxide (CHEBI:16480) is a nitrogen oxide (CHEBI:35196) nitric oxide (CHEBI:16480) is a reactive nitrogen species (CHEBI:62764)

IUPAC Names

oxidonitrogen(•)

oxoazanyl

Synonyms	Sources
(NO)^•	IUPAC
[NO]	MolBase
EDRF	ChEBI
endothelium-derived relaxing factor	ChEBI
mononitrogen monoxide	ChemIDplus
monóxido de nitrógeno	ChEBI
monoxyde d'azote	ChEBI
Nitric oxide	KEGG COMPOUND
nitric oxide	UniProt
nitrogen monooxide	IUPAC
Nitrogen monoxide	KEGG COMPOUND
nitrogen monoxide	IUPAC
nitrosyl	IUPAC
NO	KEGG COMPOUND
^•NO	ChEBI
NO^•	IUPAC
óxido de nitrógeno(II)	ChEBI
óxido nítrico	ChEBI
oxyde azotique	ChEBI
oxyde nitrique	ChEBI
Stickstoff(II)-oxid	ChEBI
Stickstoffmonoxid	ChEBI

Last Modified

21 January 2021

General Comment
2012-07-23	Nitric oxide (NO) is a relatively stable free radical. A significant air pollutant, being produced by combustion of substances in air, particularly of fossil fuels in power stations and internal combustion engines, it is also an important signalling molecule, involved in many physiological and pathological processes in mammals.