N-carbamoyl-L-aspartic acid (CHEBI:15859)

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ChEBI Name	N-carbamoyl-L-aspartic acid

ChEBI ID	CHEBI:15859

ChEBI ASCII Name	N-carbamoyl-L-aspartic acid

Definition	The L-enantiomer N-carbamoylaspartic acid.

Stars	This entity has been manually annotated by the ChEBI Team.

Secondary ChEBI IDs	CHEBI:44316, CHEBI:12496, CHEBI:7257, CHEBI:21688

Supplier Information	eMolecules:1934501

Download	Molfile XML SDF

Wikipedia	License
Vinblastine, sold under the brand name Velban among others, is a chemotherapy medication, typically used with other medications, to treat a number of types of cancer. This includes Hodgkin's lymphoma, non-small-cell lung cancer, bladder cancer, brain cancer, melanoma, and testicular cancer. It is given by injection into a vein. Most people experience some side effects. Commonly it causes a change in sensation, constipation, weakness, loss of appetite, and headaches. Severe side effects include low blood cell counts and shortness of breath. It should not be given to people who have a current bacterial infection. Use during pregnancy will likely harm the baby. Vinblastine works by blocking cell division. Vinblastine was isolated in 1958. An example of a natural herbal remedy that has since been developed into a conventional medicine, vinblastine was originally obtained from the Madagascar periwinkle. It is on the World Health Organization's List of Essential Medicines.
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Formula

C5H8N2O5

Net Charge

Average Mass

176.12740

Monoisotopic Mass

176.04332

InChI

InChI=1S/C5H8N2O5/c6-5(12)7-2(4(10)11)1-3(8)9/h2H,1H2,(H,8,9)(H,10,11)(H3,6,7,12)/t2-/m0/s1

InChIKey

HLKXYZVTANABHZ-REOHCLBHSA-N

SMILES

NC(=O)N[C@@H](CC(O)=O)C(O)=O

Roles Classification
Chemical Role(s):	Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Bronsted base). (via oxoacid )

Biological Role(s):	metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. Saccharomyces cerevisiae metabolite Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae ). (via N-carbamoylaspartic acid ) Escherichia coli metabolite Any bacterial metabolite produced during a metabolic reaction in Escherichia coli. (via N-carbamoylaspartic acid ) human metabolite Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). (via N-carbamoylaspartic acid )

ChEBI Ontology
Outgoing	N-carbamoyl-L-aspartic acid (CHEBI:15859) has role metabolite (CHEBI:25212) N-carbamoyl-L-aspartic acid (CHEBI:15859) is a N-carbamoyl-L-amino acid (CHEBI:21686) N-carbamoyl-L-aspartic acid (CHEBI:15859) is a N-carbamoylaspartic acid (CHEBI:64850) N-carbamoyl-L-aspartic acid (CHEBI:15859) is a L-aspartic acid derivative (CHEBI:83978) N-carbamoyl-L-aspartic acid (CHEBI:15859) is conjugate acid of N-carbamoyl-L-aspartate(2−) (CHEBI:32814)

Incoming	N-carbamoyl-L-aspartate(2−) (CHEBI:32814) is conjugate base of N-carbamoyl-L-aspartic acid (CHEBI:15859)

IUPAC Name

N-carbamoyl-L-aspartic acid

Synonyms	Sources
carbamyl-L-aspartic acid	ChemIDplus
Carbamyl-L-aspartic acid	HMDB
L-ureidosuccinic acid	ChemIDplus
N-(aminocarbonyl)-L-aspartic acid	ChemIDplus
N-Carbamoyl-L-aspartate	KEGG COMPOUND
N-CARBAMOYL-L-ASPARTATE	PDBeChem
N-carbamoyl-S-aspartic acid	HMDB

Citation	Type	Source
17439666	PubMed citation	Europe PMC

Last Modified

23 October 2015