rolipram (CHEBI:104872)

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ChEBI Name	rolipram

ChEBI ID	CHEBI:104872

Definition	A member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position. It is a type IV-specific phosphodiesterase (PDE4) inhibitor.

Stars	This entity has been manually annotated by the ChEBI Team.

Secondary ChEBI IDs	CHEBI:32104

Supplier Information	ChemicalBook:CB2703866, eMolecules:594068, Selleckchem:Rolipram

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Formula

C16H21NO3

Net Charge

Average Mass

275.34280

Monoisotopic Mass

275.15214

InChI

InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)

InChIKey

HJORMJIFDVBMOB-UHFFFAOYSA-N

SMILES

COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1

Roles Classification
Biological Role(s):	EC 3.1.4.* (phosphoric diester hydrolase) inhibitor An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of a phosphoric diester hydrolase (EC 3.1.4.*).

Application(s):	antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.

ChEBI Ontology
Outgoing	rolipram (CHEBI:104872) has role antidepressant (CHEBI:35469) rolipram (CHEBI:104872) has role EC 3.1.4.* (phosphoric diester hydrolase) inhibitor (CHEBI:50218) rolipram (CHEBI:104872) is a pyrrolidin-2-ones (CHEBI:74223)

Incoming	(−)-rolipram (CHEBI:40133) is a rolipram (CHEBI:104872) (+)-rolipram (CHEBI:59540) is a rolipram (CHEBI:104872)

IUPAC Name

4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one

Synonyms	Sources
4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinone	ChemIDplus
ZK 62711	ChemIDplus

Citations

Last Modified

24 February 2016