appears_in: []
contact:
  email: cogs@ncbi.nlm.nih.gov
  name: Michael Y Galperin
  orcid: 0000-0002-2265-5572
contributor:
  email: cthoyt@gmail.com
  github: cthoyt
  name: Charles Tapley Hoyt
  orcid: 0000-0003-4423-4370
depends_on: []
deprecated: false
description: 'COGs stands for Clusters of Orthologous Genes. The database was initially
  created in 1997 (Tatusov et al., PMID: 9381173) followed by several updates, most
  recently in 2014 (Galperin et al., PMID: 25428365). The current update includes
  complete genomes of 1,187 bacteria and 122 archaea that map into 1,234 genera. The
  new features include ~250 updated COG annotations with corresponding references
  and PDB links, where available; new COGs for proteins involved in CRISPR-Cas immunity,
  sporulation, and photosynthesis, and the lists of COGs grouped by pathways and functional
  systems.'
example: COG0001
example_extras: []
homepage: https://www.ncbi.nlm.nih.gov/research/cog/
keywords:
- genome
- life science
- protein
mappings:
  biolink: COG
  fairsharing: FAIRsharing.djsbw2
  go: COG_Cluster
  miriam: cog
  prefixcommons: cog
  togoid: Cog
name: Cluster of orthologous genes
namespace_in_lui: false
pattern: ^COG\d+$
preferred_prefix: cog.cluster
prefix: cog.cluster
providers:
- code: bio2rdf
  description: Bio2RDF is an open-source project that uses Semantic Web technologies
    to build and provide the largest network of Linked Data for the Life Sciences.
    Bio2RDF defines a set of simple conventions to create RDF(S) compatible Linked
    Data from a diverse set of heterogeneously formatted sources obtained from multiple
    data providers.
  homepage: https://bio2rdf.org
  name: Bio2RDF
  uri_format: http://bio2rdf.org/cog:$1
publications:
- doi: 10.1126/science.278.5338.631
  pubmed: '9381173'
  title: A genomic perspective on protein families
  year: 1997
- doi: 10.1093/nar/gku1223
  pmc: PMC4383993
  pubmed: '25428365'
  title: Expanded microbial genome coverage and improved protein family annotation
    in the COG database
  year: 2014
synonyms:
- COG_Cluster
- cog
uri_format: https://www.ncbi.nlm.nih.gov/research/cog/cog/$1
