AlzGene - Gene overview of all published AD-association studies for ABCA1
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 Gene: ABCA1  (TGD; ABC1; CERP; ABC-1; HDLDT1)  Entrez Gene
 Protein: ATP-binding cassette, sub-family A member 1  (ATP binding cassette transporter 1; cholesterol efflux regulatory protein; high density lipoprotein deficiency, Tangier type, 1; ATP-binding cassette 1)  ProteinLink
 Chromosome: 9   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Corder, 2008
 Overlaps with
Katzov, 2004		 CL  3  (detail)  938
(-)		U--397
(-)		-n.a.
Giedraitis, 2009
 Sweden (ULSAM) CL  3  (detail)  86
(0%)		C80.2
(72-85)		-404
(0%)		81.8
(80-84)		Negative
Katzov, 2004
 UK (II) CL  3  (detail)  335
(60%)		U72.9 + 9.2
(-)		80.7 + 8
(-)		110
(46%)		77.1 + 9.1
(-)		Negative
Katzov, 2004
 UK (I) CL  4  (detail)  121
(58%)		C52.4 + 6.8
(-)		57.8 + 6.3
(-)		152
(38%)		58.2 + 9.8
(-)		Positive
Katzov, 2004
 Sweden (Set C) CL  3  (detail)  147
(69%)		C76.9 + 6.9
(-)		82.1 + 6.3
(-)		326
(66%)		83.6 + 3.2
(-)		Positive
Katzov, 2004
 Sweden (Set A) CL  5  (detail)  390
(57%)		M72.4 + 8
(-)		76.9 + 7.6
(-)		185
(58%)		73.2 + 9.7
(-)		Positive
Koelsch, 2006
 Germany CL  2  (detail)  241
(71%)		C-73.2 + 9.4
(-)		294
(54%)		71.8 + 8.1
(-)		Negative
Li, 2004
 USA (WashU) CL  9  (detail)  419
(-)		C-77.5 + 7.5
(-)		377
(-)		-Negative
Li, 2008
 Canada CL  13  (detail)  753
(58%)		C71.9 + 8.5
(-)		77.8 + 8.6
(-)		736
(64%)		73.4 + 7.9
(-)		Negative
Reiman, 2007
 USA, Netherlands CL  13  (detail)  861
(-)		M-74.9 + 6.6
(-)		550
(-)		77.4 + 7.3
(-)		Negative
Reynolds, 2009
 Overlaps with
Katzov, 2004		 CL  46  (detail)  896
(-)		M--248
(-)		-Positive
Reynolds, 2010
 Overlaps with
Katzov, 2004		 PO  1  (detail)  1270
(-)		C--2203
(55%)		-Positive
Rodriguez-Rodriguez, 2007
 Overlaps with
Rodriguez, 2010		 CL  5  (detail)  372
(66%)		C72.3 + 8.4
(48-94)		75.8 + 8.5
(50-97)		440
(69%)		80.8 + 7.7
(51-100)		n.a.
Rodriguez-Rodriguez, 2009
 Overlaps with
Rodriguez, 2010		 CL  2  (detail)  325
(66%)		C73.5 + 6.7
(60-93)		76.9 + 6.7
(62-97)		383
(69%)		80.9 + 7.8
(62-100)		n.a.
Rodriguez-Rodriguez, 2010
 Spain CL  1  (detail)  631
(65%)		C72.8 + 7.8
(60-100)		75.9 + 8.1
(61-109)		731
(65%)		78.6 + 9.4
(60-104)		Positive
Shibata, 2005
 USA, Canada CL  4  (detail)  218
(53%)		C75 + 8.4
(-)		-195
(52%)		73.1 + 9.3
(-)		Negative
Sundar, 2006
 USA CL  2  (detail)  992
(66%)		C72.3 + 6.3
(-)		-699
(62%)		75.3 + 5.6
(-)		Positive
Wahrle, 2007
 USA & UK CL  1  (detail)  1225
(-)		M--1431
(-)		-Negative
Wollmer, 2003
 Europe (mixed) CL  2  (detail)  169
(58%)		C69 + 5.4
(-)		73.5 + 5.5
(-)		166
(49%)		70.1 + 6.3
(-)		Positive
 Asian
Chu, 2007
 China CL  19  (detail)  279
(75%)		C-79 + 7
(65-97)		279
(72%)		72 + 5.5
(65-90)		Positive
Wang, 2007
 China CL  1  (detail)  168
(56%)		C69.3 + 7.3
(-)		73.5 + 8.4
(-)		215
(63%)		72.3 + 7.6
(-)		Positive
 Other/Mixed
Li, 2004
 USA (UCSD) CL  2  (detail)  203
(-)		C-78.8 + 7.4
(-)		394
(-)		-Negative
Li, 2004
 UK CL  1  (detail)  358
(-)		C-75.7 + 7
(-)		395
(-)		-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Reynolds, 2009
 Sweden  46  (detail)   379
(-)		C--1955
(-)		-Positive
Wavrant-de Vrieze, 2007
 USA (NIMH, NCRAD)  4  (detail)  332680
(72%)		M73.7 + 8.3
(-)		-125
(55%)		75.8 + 6.8
(-)		Positive
 Hispanic
Shibata, 2005
 Mixed  4  (detail)  118-U----Positive
 Other/Mixed
Bertram, 2005
 USA (NIMH)  7  (detail)  189789
(-)		M71.2 + 7.4
(50-97)		-348
(-)		-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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