AmiGO 2: Term Details for "PRC1 complex" (GO:0035102)

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Term Information

Accession: GO:0035102
Name: PRC1 complex
Ontology: cellular_component
Synonyms: Polycomb repressive complex 1
Alternate IDs: None
Definition: A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling. Source: GOC:bf, PMID:10412979
Comment: In Drosophila the core subunits are Pc (Polycomb), Psc (Posterior sex combs), Ph (Polyhomeotic) and Sce (Sex comb extra). In mammals, which have several orthologs for each of the Drosophila core proteins, a family of distinct PRC1-like complexes seem to exist which contain at least some PcG proteins in mutually exclusive manner.
History: See term history for GO:0035102 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to PRC1 complex (excluding "regulates").; Link to all direct and indirect annotations to PRC1 complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for PRC1 complex (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
CARO:0000006 material anatomical entity
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0005575 cellular_component
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0003824 catalytic activity
CL:0000000 cell
GO:0110165 cellular anatomical structure
GO:0016755 aminoacyltransferase activity
GO:0140096 catalytic activity, acting on a protein
GO:0005622 intracellular anatomical structure
GO:0003674 molecular_function
GO:0043226 organelle
GO:0043229 intracellular organelle
GO:0043227 membrane-bounded organelle
GO:0032991 protein-containing complex
GO:0019787 ubiquitin-like protein transferase activity
GO:1902494 catalytic complex
GO:0043231 intracellular membrane-bounded organelle
GO:0061659 ubiquitin-like protein ligase activity
GO:0004842 ubiquitin-protein transferase activity
GO:0140535 intracellular protein-containing complex
GO:0005634 nucleus
GO:1990234 transferase complex
GO:0061630 ubiquitin protein ligase activity
GO:0140513 nuclear protein-containing complex
GO:0000151 ubiquitin ligase complex
GO:0000152 nuclear ubiquitin ligase complex
GO:0031519 PcG protein complex
GO:0035102 PRC1 complex

Parents of PRC1 complex (GO:0035102)

subject	relation	object
PRC1 complex	is_a	PcG protein complex (GO:0031519)
PRC1 complex	RO:0002162	Eukaryota (NCBITaxon:2759)
PRC1 complex	is_a	nuclear ubiquitin ligase complex (GO:0000152)

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