AmiGO 2: Term Details for "NMDA selective glutamate receptor complex" (GO:0017146)

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Term Information

Accession: GO:0017146
Name: NMDA selective glutamate receptor complex
Ontology: cellular_component
Synonyms: N-methyl-D-aspartate selective glutamate receptor complex, NMDA-selective glutamate receptor
Alternate IDs: None
Definition: An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD. Source: PMID:8294079
Comment: None
History: See term history for GO:0017146 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to NMDA selective glutamate receptor complex (excluding "regulates").; Link to all direct and indirect annotations to NMDA selective glutamate receptor complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for NMDA selective glutamate receptor complex (excluding "regulates").

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
CARO:0000006 material anatomical entity
GO:0065007 biological regulation
CARO:0000003 connected anatomical structure
GO:0051179 localization
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0110165 cellular anatomical structure
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0051234 establishment of localization
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
GO:0006810 transport
GO:0007154 cell communication
GO:0071944 cell periphery
GO:0051716 cellular response to stimulus
GO:0022836 gated channel activity
GO:0022834 ligand-gated channel activity
GO:0016020 membrane
GO:0003674 molecular_function
GO:0005216 monoatomic ion channel activity
GO:0006811 monoatomic ion transport
GO:0015849 organic acid transport
GO:0015711 organic anion transport
GO:0050794 regulation of cellular process
GO:0007165 signal transduction
GO:0023052 signaling
GO:0055085 transmembrane transport
GO:0022857 transmembrane transporter activity
GO:0006865 amino acid transport
GO:0046942 carboxylic acid transport
GO:0007166 cell surface receptor signaling pathway
GO:0015267 channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0098796 membrane protein complex
GO:0060089 molecular transducer activity
GO:0034220 monoatomic ion transmembrane transport
GO:0030594 neurotransmitter receptor activity
GO:1903825 organic acid transmembrane transport
GO:0022803 passive transmembrane transporter activity
GO:0005886 plasma membrane
GO:0032991 protein-containing complex
GO:0038023 signaling receptor activity
GO:0005215 transporter activity
GO:0003333 amino acid transmembrane transport
GO:1905039 carboxylic acid transmembrane transport
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0007215 glutamate receptor signaling pathway
GO:1990806 ligand-gated ion channel signaling pathway
GO:0015075 monoatomic ion transmembrane transporter activity
GO:0005342 organic acid transmembrane transporter activity
GO:0008514 organic anion transmembrane transporter activity
GO:0098797 plasma membrane protein complex
GO:0043235 receptor complex
GO:0004888 transmembrane signaling receptor activity
GO:0022835 transmitter-gated channel activity
GO:1990351 transporter complex
GO:0015171 amino acid transmembrane transporter activity
GO:0046943 carboxylic acid transmembrane transporter activity
GO:0008066 glutamate receptor activity
GO:0015318 inorganic molecular entity transmembrane transporter activity
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0098802 plasma membrane signaling receptor complex
GO:1902495 transmembrane transporter complex
GO:0022824 transmitter-gated monoatomic ion channel activity
GO:0022832 voltage-gated channel activity
GO:0004970 glutamate-gated receptor activity
GO:0022890 inorganic cation transmembrane transporter activity
GO:0034702 monoatomic ion channel complex
GO:0098878 neurotransmitter receptor complex
GO:0005244 voltage-gated monoatomic ion channel activity
GO:0008328 ionotropic glutamate receptor complex
GO:0004972 NMDA glutamate receptor activity
GO:0017146 NMDA selective glutamate receptor complex

Parents of NMDA selective glutamate receptor complex (GO:0017146)

subject	relation	object
NMDA selective glutamate receptor complex	RO:0002215	NMDA glutamate receptor activity (GO:0004972)
NMDA selective glutamate receptor complex	is_a	ionotropic glutamate receptor complex (GO:0008328)
NMDA selective glutamate receptor complex	RO:0002162	Metazoa (NCBITaxon:33208)

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