AmiGO 2: Term Details for "cohesin complex" (GO:0008278)

Accession: GO:0008278
Name: cohesin complex
Ontology: cellular_component
Synonyms: SMC/kleisin ring complex, SMC complex, cohesin core heterodimer, nuclear cohesin complex, 14S cohesin, 9S cohesin, Smc1-Smc3 complex
Alternate IDs: GO:0000798, GO:0008280, GO:0043222, GO:0008279
Definition: A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). Source: GOC:sp, PMID:9887095, GOC:jl, GOC:vw
Comment: None
History: See term history for GO:0008278 at QuickGO
Chem. react.: None
Subset: goslim_pir
Related: Link to all genes and gene products annotated to cohesin complex (excluding "regulates").; Link to all direct and indirect annotations to cohesin complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for cohesin complex (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
cohesin complex	BFO:0000050	chromosome (GO:0005694)
cohesin complex	is_a	protein-containing complex (GO:0032991)
cohesin complex	RO:0002162	cellular organisms (NCBITaxon:131567)
cohesin complex	RO:0002215	sister chromatid cohesion (GO:0007062)

subject	relation	object
meiotic cohesin complex (GO:0030893)	is_a	cohesin complex
mitotic cohesin complex (GO:0030892)	is_a	cohesin complex

GONUTS Add usage comments for this term on the GONUTS wiki.