Term Information

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Accession
GO:0005665
Name
RNA polymerase II, core complex
Ontology
cellular_component
Synonyms
DNA-directed RNA polymerase II, core complex, RNA polymerase II complex, RNAP II complex
Alternate IDs
None
Definition
RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. Source: GOC:krc, GOC:mtg_sensu
Comment
None
History
See term history for GO:0005665 at QuickGO
Chem. react.
None
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Parents of RNA polymerase II, core complex (GO:0005665)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
RNA polymerase II, core complex [BFO:0000050 relation] BFO:0000050  RNA polymerase II, holoenzyme (GO:0016591)
RNA polymerase II, core complex [is_a relation] is_a  nuclear DNA-directed RNA polymerase complex (GO:0055029)

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