AmiGO 2: Term Details for "death receptor activity" (GO:0005035)

Accession: GO:0005035
Name: death receptor activity
Ontology: molecular_function
Synonyms: apoptosis-activating receptor activity
Alternate IDs: None
Definition: Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death. Source: GOC:BHF, GOC:bf, PMID:10209153, GOC:mtg_apoptosis, GOC:ecd, GOC:rl
Comment: None
History: See term history for GO:0005035 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to death receptor activity (excluding "regulates").; Link to all direct and indirect annotations to death receptor activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for death receptor activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
death receptor activity	is_a	transmembrane signaling receptor activity (GO:0004888)
death receptor activity	BFO:0000050	programmed cell death (GO:0012501)

subject	relation	object
tumor necrosis factor receptor activity (GO:0005031)	is_a	death receptor activity
TRAIL receptor activity (GO:0036463)	is_a	death receptor activity
death receptor agonist activity (GO:0038177)	RO:0002213	death receptor activity

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