achcar11

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Abstract
Previous models of glycolysis in the sleeping sickness parasite Trypanosoma brucei assumed that the core part of glycolysis in this unicellular parasite is tightly compartimentalized within an organelle, the glycosome, which had previously been shown to contain most of the glycolytic enzymes. The glycosomes were assumed to be largely impermeable, and exchange of metabolites between the cytosol and the glycosome was assumed to be regulated by specific transporters in the glycosomal membrane. This tight compartmentalization was considered to be essential for parasite viability. Recently, size-specific metabolite pores were discovered in the membrane of glycosomes. These channels are proposed to allow smaller metabolites to diffuse across the membrane but not larger ones. In light of this new finding, we re-analyzed the model taking into account uncertainty about the topology of the metabolic system in T. brucei, as well as uncertainty about the values of all parameters of individual enzymatic reactions. Our analysis shows that these newly-discovered nonspecific pores are not necessarily incompatible with our current knowledge of the glycosomal metabolic system, provided that the known cytosolic activities of the glycosomal enzymes play an important role in the regulation of glycolytic fluxes and the concentration of metabolic intermediates of the pathway.

Unit definitions have no effect on the numerical analysis of the model. It remains the responsibility of the modeler to ensure the internal numerical consistency of the model. If units are provided, however, the consistency of the model units will be checked.

Name Definition
Id Name Spatial Dimensions Size
default_compartment 3.0 1.0
Id Name Initial Quantity Compartment Fixed
ADPc 0.77 default_compartment
ADPg 0.77 default_compartment
AMPc 0.83 default_compartment
AMPg 0.83 default_compartment
ATPc 2.25 default_compartment
ATPg 2.25 default_compartment
BPGA13c 0.01 default_compartment
BPGA13g 0.4 default_compartment
DHAPc 4.6 default_compartment
DHAPg 4.6 default_compartment
Fru16BPc 0.01 default_compartment
Fru16BPg 13.0 default_compartment
Fru6Pc 0.2 default_compartment
Fru6Pg 0.2 default_compartment
GA3Pc 0.01 default_compartment
GA3Pg 0.14 default_compartment
Glc6Pc 0.8 default_compartment
Glc6Pg 0.8 default_compartment
Glcc 0.01 default_compartment
Glce 5.0 default_compartment
Glcg 0.01 default_compartment
Gly3Pc 1.5 default_compartment
Gly3Pg 1.5 default_compartment
Glyc 1e-06 default_compartment
Glye 1e-06 default_compartment
Glyg 1e-06 default_compartment
NADHc 0.0005 default_compartment
NADHg 0.1 default_compartment
NADc 0.36 default_compartment
NADg 3.9 default_compartment
PEPc 1.4 default_compartment
PGA2c 0.5 default_compartment
PGA3c 17.0 default_compartment
PGA3g 17.0 default_compartment
Pic 0.0 default_compartment
Pig 0.0 default_compartment
Pyrc 14.0 default_compartment
Pyre 0.0 default_compartment

Initial assignments are expressions that are evaluated at time=0. It is not recommended to create initial assignments for all model entities. Restrict the use of initial assignments to cases where a value is expressed in terms of values or sizes of other model entities. Note that it is not permitted to have both an initial assignment and an assignment rule for a single model entity.

Definition
Id Name Objective Coefficient Reaction Equation And Kinetic Law Flux Bounds
AKc {2.0}ADPc = AMPc + ATPc

(AKcAKck1*ADPc^2-AKcAKck2*AMPc*ATPc)/cytosol
AKg {44.5116}ADPg = {22.2558}AMPg + {22.2558}ATPg

(AKgAKgk1*ADPg^2-AKgAKgk2*AMPg*ATPg)/cytosol
ALDc ALDc Fru16BPc = DHAPc + GA3Pc

(ALDcALDcVmax*Fru16BPc*(1.-(DHAPc*GA3Pc)/(ALDcALDgKeq*Fru16BPc)))/(ALDcALDgKmFru16BP*cytosol*(1.+ADPc/ALDcALDgKiADP+AMPc/ALDcALDgKiAMP+ATPc/ALDcALDgKiATP)*(1.+DHAPc/ALDcALDgKmDHAP+Fru16BPc/(ALDcALDgKmFru16BP*(1.+ADPc/ALDcALDgKiADP+AMPc/ALDcALDgKiAMP+ATPc/ALDcALDgKiATP))+GA3Pc/ALDcALDgKmGA3P+(DHAPc*GA3Pc)/(ALDcALDgKmDHAP*ALDcALDgKmGA3P)+(Fru16BPc*GA3Pc)/(ALDcALDgKiGA3P*ALDcALDgKmFru16BP*(1.+ADPc/ALDcALDgKiADP+AMPc/ALDcALDgKiAMP+ATPc/ALDcALDgKiATP))))
ALDg ALDg {22.2558}Fru16BPg = {22.2558}DHAPg + {22.2558}GA3Pg

(ALDgALDgVmax*Fru16BPg*(1.-(DHAPg*GA3Pg)/(ALDgALDgKeq*Fru16BPg)))/(ALDgALDgKmFru16BP*cytosol*(1.+ADPg/ALDgALDgKiADP+AMPg/ALDgALDgKiAMP+ATPg/ALDgALDgKiATP)*(1.+DHAPg/ALDgALDgKmDHAP+Fru16BPg/(ALDgALDgKmFru16BP*(1.+ADPg/ALDgALDgKiADP+AMPg/ALDgALDgKiAMP+ATPg/ALDgALDgKiATP))+GA3Pg/ALDgALDgKmGA3P+(DHAPg*GA3Pg)/(ALDgALDgKmDHAP*ALDgALDgKmGA3P)+(Fru16BPg*GA3Pg)/(ALDgALDgKiGA3P*ALDgALDgKmFru16BP*(1.+ADPg/ALDgALDgKiADP+AMPg/ALDgALDgKiAMP+ATPg/ALDgALDgKiATP))))
ATPuc ATPc = ADPc

(ATPucATPuck*ATPc)/(cytosol*ADPc)
BPGA13tg {22.2558}BPGA13g = BPGA13c

(BPGA13tgBPGA13tgk*(-BPGA13c+BPGA13g))/cytosol
DHAPtg DHAPc = {22.2558}DHAPg

(DHAPtgDHAPtgk*(DHAPc-DHAPg))/cytosol
ENOc PGA2c = PEPc

(ENOcENOcVmax*(1-PEPc/(ENOcENOcKeq*PGA2c))*PGA2c)/(cytosol*ENOcENOcKmPGA2*(1.+PEPc/ENOcENOcKmPEP+PGA2c/ENOcENOcKmPGA2))
F6Ptg {22.2558}Fru6Pg = Fru6Pc

(F6PtgF6Ptgk*(-Fru6Pc+Fru6Pg))/cytosol
G3PDHc DHAPc + NADHc = Gly3Pc + NADc

(G3PDHcG3PDHcVmax*NADHc*DHAPc*(1.-(NADc*Gly3Pc)/(G3PDHcG3PDHgKeq*NADHc*DHAPc)))/(cytosol*G3PDHcG3PDHgKmDHAP*G3PDHcG3PDHgKmNADH*(1.+NADHc/G3PDHcG3PDHgKmNADH+NADc/G3PDHcG3PDHgKmNAD)*(1.+DHAPc/G3PDHcG3PDHgKmDHAP+Gly3Pc/G3PDHcG3PDHgKmGly3P))
G3PDHg {22.2558}DHAPg + {22.2558}NADHg = {22.2558}Gly3Pg + {22.2558}NADg

(G3PDHgG3PDHgVmax*DHAPg*NADHg*(1.-(Gly3Pg*NADg)/(G3PDHgG3PDHgKeq*DHAPg*NADHg)))/(cytosol*G3PDHgG3PDHgKmDHAP*G3PDHgG3PDHgKmNADH*(1.+DHAPg/G3PDHgG3PDHgKmDHAP+Gly3Pg/G3PDHgG3PDHgKmGly3P)*(1.+NADHg/G3PDHgG3PDHgKmNADH+NADg/G3PDHgG3PDHgKmNAD))
G6PPc Glc6Pc = Glcc

(G6PPcG6PPcVmax*Glc6Pc*(1-Glcc/(G6PPcG6PPcKeq*Glc6Pc)))/(cytosol*G6PPcG6PPcKmGlc6P*(1.+Glc6Pc/G6PPcG6PPcKmGlc6P+Glcc/G6PPcG6PPcKmGlc))
G6Ptg {22.2558}Glc6Pg = Glc6Pc

(G6PtgG6Ptgk*(-Glc6Pc+Glc6Pg))/cytosol
GA3Ptg {22.2558}GA3Pg = GA3Pc

(GA3PtgGA3Ptgk*(-GA3Pc+GA3Pg))/cytosol
GAPDHc GA3Pc + NADc + Pic = BPGA13c + NADHc

(GAPDHcGAPDHcVmax*NADc*GA3Pc*(1.-(NADHc*BPGA13c)/(GAPDHcGAPDHcKeq*NADc*GA3Pc)))/(cytosol*GAPDHcGAPDHcKmGA3P*GAPDHcGAPDHcKmNAD*(1.+NADHc/GAPDHcGAPDHcKmNADH+NADc/GAPDHcGAPDHcKmNAD)*(1.+GA3Pc/GAPDHcGAPDHcKmGA3P+BPGA13c/GAPDHcGAPDHcKmBPGA13))
GAPDHg Pig + {22.2558}GA3Pg + {22.2558}NADg = {22.2558}BPGA13g + {22.2558}NADHg

(GAPDHgGAPDHgVmax*GA3Pg*NADg*(1.-(NADHg*BPGA13g)/(GAPDHgGAPDHgKeq*GA3Pg*NADg)))/(cytosol*GAPDHgGAPDHgKmGA3P*GAPDHgGAPDHgKmNAD*(1.+NADHg/GAPDHgGAPDHgKmNADH+NADg/GAPDHgGAPDHgKmNAD)*(1.+GA3Pg/GAPDHgGAPDHgKmGA3P+BPGA13g/GAPDHgGAPDHgKmBPGA13))
GKc ADPc + Gly3Pc = ATPc + Glyc

(GKcGKcVmax*ADPc*Gly3Pc*(1.-(ATPc*Glyc)/(GKcGKgKeq*ADPc*Gly3Pc)))/(cytosol*GKcGKgKmADP*GKcGKgKmGly3P*(1.+ADPc/GKcGKgKmADP+ATPc/GKcGKgKmATP)*(1.+Gly3Pc/GKcGKgKmGly3P+Glyc/GKcGKgKmGly))
GKg {22.2558}ADPg + {22.2558}Gly3Pg = {22.2558}ATPg + {22.2558}Glyg

(GKgGKgVmax*ADPg*Gly3Pg*(1.-(ATPg*Glyg)/(GKgGKgKeq*ADPg*Gly3Pg)))/(cytosol*GKgGKgKmADP*GKgGKgKmGly3P*(1.+ADPg/GKgGKgKmADP+ATPg/GKgGKgKmATP)*(1.+Gly3Pg/GKgGKgKmGly3P+Glyg/GKgGKgKmGly))
GPOc Gly3Pc = DHAPc

(GPOcGPOcVmax*Gly3Pc)/(cytosol*GPOcGPOcKmGly3P*(1.+((1.+SHAM/GPOcGPOcKiSHAM)*Gly3Pc)/GPOcGPOcKmGly3P))
GlcTc Glce = Glcc

(GlcTcGlcTcVmax*(Glce-Glcc))/(cytosol*(GlcTcGlcTcKmGlc+Glce+Glcc+(GlcTcGlcTcalpha*Glce*Glcc)/GlcTcGlcTcKmGlc))
GlcTg Glcc = {22.2558}Glcg

(GlcTgGlcTgk*Glcc-GlcTgGlcTgk*Glcg)/cytosol
Gly3Ptg {22.2558}Gly3Pg = Gly3Pc

(Gly3PtgGly3Ptgk*(-Gly3Pc+Gly3Pg))/cytosol
GlyTc Glyc = Glye

(GlyTcGlyTck*(-Glye+Glyc)+(GlyTcGlyTcVrmax*GlyTcGlyTcy*(-Glye+Glyc))/(GlyTcGlyTcKmGlye*GlyTcGlyTcy+GlyTcGlyTcy*Glye+Glyc+(GlyTcGlyTcx*(1.-GlyTcGlyTcx+GlyTcGlyTcy)*Glye*Glyc)/(GlyTcGlyTcKmGlye*GlyTcGlyTcy)))/cytosol
Glytg {22.2558}Glyg = Glyc

(GlytgGlytgk*(-Glyc+Glyg))/cytosol
HXKc ATPc + Glcc = ADPc + Glc6Pc

(HXKcHXKcVmax*ATPc*(1.-(ADPc*Glc6Pc)/(HXKcHXKgKeq*ATPc*Glcc))*Glcc)/(cytosol*HXKcHXKgKmATP*HXKcHXKgKmGlc*(1.+ADPc/HXKcHXKgKmADP+ATPc/HXKcHXKgKmATP)*(1.+Glc6Pc/HXKcHXKgKmGlc6P+Glcc/HXKcHXKgKmGlc))
HXKg {22.2558}ATPg + {22.2558}Glcg = {22.2558}ADPg + {22.2558}Glc6Pg

(HXKgHXKgVmax*ATPg*(1.-(ADPg*Glc6Pg)/(HXKgHXKgKeq*ATPg*Glcg))*Glcg)/(cytosol*HXKgHXKgKmATP*HXKgHXKgKmGlc*(1.+ADPg/HXKgHXKgKmADP+ATPg/HXKgHXKgKmATP)*(1.+Glc6Pg/HXKgHXKgKmGlc6P+Glcg/HXKgHXKgKmGlc))
PFKc ATPc + Fru6Pc = ADPc + Fru16BPc

(PFKcPFKcVmax*PFKcPFKgKi1*ATPc*(1.-(ADPc*Fru16BPc)/(PFKcPFKgKeq*ATPc*Fru6Pc))*Fru6Pc)/(cytosol*PFKcPFKgKmATP*PFKcPFKgKmFru6P*(PFKcPFKgKi1+Fru16BPc)*(PFKcPFKgKsATP/PFKcPFKgKmATP+ADPc/PFKcPFKgKmADP+ATPc/PFKcPFKgKmATP+(ADPc*Fru16BPc)/(PFKcPFKgKi2*PFKcPFKgKmADP)+Fru6Pc/PFKcPFKgKmFru6P+(ATPc*Fru6Pc)/(PFKcPFKgKmATP*PFKcPFKgKmFru6P)))
PFKg {22.2558}ATPg + {22.2558}Fru6Pg = {22.2558}ADPg + {22.2558}Fru16BPg

(PFKgPFKgKi1*PFKgPFKgVmax*ATPg*(1.-(ADPg*Fru16BPg)/(PFKgPFKgKeq*ATPg*Fru6Pg))*Fru6Pg)/(cytosol*PFKgPFKgKmATP*PFKgPFKgKmFru6P*(PFKgPFKgKi1+Fru16BPg)*(PFKgPFKgKsATP/PFKgPFKgKmATP+ADPg/PFKgPFKgKmADP+ATPg/PFKgPFKgKmATP+(ADPg*Fru16BPg)/(PFKgPFKgKi2*PFKgPFKgKmADP)+Fru6Pg/PFKgPFKgKmFru6P+(ATPg*Fru6Pg)/(PFKgPFKgKmATP*PFKgPFKgKmFru6P)))
PGA3Tg {22.2558}PGA3g = PGA3c

(-(PGA3TgPGA3Tgk*PGA3c)+PGA3TgPGA3Tgk*PGA3g)/cytosol
PGAMc PGA3c = PGA2c

(PGAMcPGAMcVmax*(1-PGA2c/(PGAMcPGAMcKeq*PGA3c))*PGA3c)/(cytosol*PGAMcPGAMcKmPGA3*(1.+PGA2c/PGAMcPGAMcKmPGA2+PGA3c/PGAMcPGAMcKmPGA3))
PGIc Glc6Pc = Fru6Pc

(PGIcPGIcVmax*(1.-Fru6Pc/(PGIcPGIgKeq*Glc6Pc))*Glc6Pc)/(cytosol*PGIcPGIgKmGlc6P*(1.+Fru6Pc/PGIcPGIgKmFru6P+Glc6Pc/PGIcPGIgKmGlc6P))
PGIg {22.2558}Glc6Pg = {22.2558}Fru6Pg

(PGIgPGIgVmax*(1-Fru6Pg/(PGIgPGIgKeq*Glc6Pg))*Glc6Pg)/(cytosol*PGIgPGIgKmGlc6P*(1.+Fru6Pg/PGIgPGIgKmFru6P+Glc6Pg/PGIgPGIgKmGlc6P))
PGKc BPGA13c + ADPc = PGA3c + ATPc

(PGKcPGKcVmax*ADPc*BPGA13c*(1.-(ATPc*PGA3c)/(PGKcPGKgKeq*ADPc*BPGA13c)))/(cytosol*PGKcPGKgKmADP*PGKcPGKgKmBPGA13*(1.+ADPc/PGKcPGKgKmADP+ATPc/PGKcPGKgKmATP)*(1.+BPGA13c/PGKcPGKgKmBPGA13+PGA3c/PGKcPGKgKmPGA3))
PGKg {22.2558}BPGA13g + {22.2558}ADPg = {22.2558}PGA3g + {22.2558}ATPg

(PGKgPGKgVmax*ADPg*BPGA13g*(1.-(ATPg*PGA3g)/(PGKgPGKgKeq*ADPg*BPGA13g)))/(cytosol*PGKgPGKgKmADP*PGKgPGKgKmBPGA13*(1.+ADPg/PGKgPGKgKmADP+ATPg/PGKgPGKgKmATP)*(1.+BPGA13g/PGKgPGKgKmBPGA13+PGA3g/PGKgPGKgKmPGA3))
PYKc ADPc + PEPc = ATPc + Pyrc

(PYKcPYKcVmax*ADPc*(PEPc/(PYKcPYKcKmPEP*(1.+ADPc/PYKcPYKcKiADP+ATPc/PYKcPYKcKiATP)))^PYKcPYKcn*(1.-(ATPc*Pyrc)/(PYKcPYKcKeq*ADPc*PEPc)))/(cytosol*PYKcPYKcKmADP*(1.+ADPc/PYKcPYKcKmADP+ATPc/PYKcPYKcKmATP)*(1.+(PEPc/(PYKcPYKcKmPEP*(1.+ADPc/PYKcPYKcKiADP+ATPc/PYKcPYKcKiATP)))^PYKcPYKcn+Pyrc/PYKcPYKcKmPyr))
PyrTc Pyrc = Pyre

(PyrTcPyrTcVmax*Pyrc)/(cytosol*PyrTcPyrTcKmPyr*(1.+Pyrc/PyrTcPyrTcKmPyr))
TPIc DHAPc = GA3Pc

(TPIcTPIcVmax*DHAPc*(1-GA3Pc/(TPIcTPIgKeq*DHAPc)))/(cytosol*TPIcTPIgKmDHAP*(1.+DHAPc/TPIcTPIgKmDHAP+GA3Pc/TPIcTPIgKmGA3P))
TPIg {22.2558}DHAPg = {22.2558}GA3Pg

(TPIgTPIgVmax*DHAPg*(1-GA3Pg/(TPIgTPIgKeq*DHAPg)))/(cytosol*TPIgTPIgKmDHAP*(1.+DHAPg/TPIgTPIgKmDHAP+GA3Pg/TPIgTPIgKmGA3P))

Global parameters

Id Value
AKcAKck1 442.0
AKcAKck2 1000.0
AKgAKgk1 442.0
AKgAKgk2 1000.0
ALDcALDcVmax 0.056
ALDcALDgKeq 0.084
ALDcALDgKiADP 1.51
ALDcALDgKiAMP 3.65
ALDcALDgKiATP 0.68
ALDcALDgKiGA3P 0.098
ALDcALDgKmDHAP 0.015
ALDcALDgKmFru16BP 0.009
ALDcALDgKmGA3P 0.067
ALDgALDgKeq 0.084
ALDgALDgKiADP 1.51
ALDgALDgKiAMP 3.65
ALDgALDgKiATP 0.68
ALDgALDgKiGA3P 0.098
ALDgALDgKmDHAP 0.015
ALDgALDgKmFru16BP 0.009
ALDgALDgKmGA3P 0.067
ALDgALDgVmax 560.0
ATPucATPuck 50.0
BPGA13tgBPGA13tgk 1000.0
DHAPtgDHAPtgk 1000.0
ENOcENOcKeq 4.12
ENOcENOcKmPEP 0.24
ENOcENOcKmPGA2 0.054
ENOcENOcVmax 598.0
EXTERNAL 0.0
F6PtgF6Ptgk 1000.0
G3PDHcG3PDHcVmax 0.047
G3PDHcG3PDHgKeq 17085.0
G3PDHcG3PDHgKmDHAP 0.1
G3PDHcG3PDHgKmGly3P 2.0
G3PDHcG3PDHgKmNAD 0.4
G3PDHcG3PDHgKmNADH 0.01
G3PDHgG3PDHgKeq 17085.0
G3PDHgG3PDHgKmDHAP 0.1
G3PDHgG3PDHgKmGly3P 2.0
G3PDHgG3PDHgKmNAD 0.4
G3PDHgG3PDHgKmNADH 0.01
G3PDHgG3PDHgVmax 465.0
G6PPcG6PPcKeq 268.0
G6PPcG6PPcKmGlc 5.0
G6PPcG6PPcKmGlc6P 5.0
G6PPcG6PPcVmax 1.0
G6PtgG6Ptgk 1000.0
GA3PtgGA3Ptgk 1000.0
GAPDHcGAPDHcKeq 0.066
GAPDHcGAPDHcKmBPGA13 0.14
GAPDHcGAPDHcKmGA3P 0.17
GAPDHcGAPDHcKmNAD 0.04
GAPDHcGAPDHcKmNADH 0.007
GAPDHcGAPDHcVmax 144.18
GAPDHgGAPDHgKeq 0.066
GAPDHgGAPDHgKmBPGA13 0.1
GAPDHgGAPDHgKmGA3P 0.15
GAPDHgGAPDHgKmNAD 0.45
GAPDHgGAPDHgKmNADH 0.02
GAPDHgGAPDHgVmax 576.72
GKcGKcVmax 0.02
GKcGKgKeq 0.000837
GKcGKgKmADP 0.56
GKcGKgKmATP 0.24
GKcGKgKmGly 0.44
GKcGKgKmGly3P 3.83
GKgGKgKeq 0.000837
GKgGKgKmADP 0.56
GKgGKgKmATP 0.24
GKgGKgKmGly 0.44
GKgGKgKmGly3P 3.83
GKgGKgVmax 200.0
GPOcGPOcKiSHAM 0.021
GPOcGPOcKmGly3P 1.7
GPOcGPOcVmax 368.0
GlcTcGlcTcKmGlc 1.1
GlcTcGlcTcVmax 111.7
GlcTcGlcTcalpha 0.75
GlcTgGlcTgk 250000.0
Gly3PtgGly3Ptgk 1000.0
GlyTcGlyTcKmGlye 0.17
GlyTcGlyTcVrmax 85.0
GlyTcGlyTck 8.5
GlyTcGlyTcx 1.0
GlyTcGlyTcy 1.0
GlytgGlytgk 1000.0
HXKcHXKcVmax 0.1929
HXKcHXKgKeq 759.0
HXKcHXKgKmADP 0.126
HXKcHXKgKmATP 0.116
HXKcHXKgKmGlc 0.1
HXKcHXKgKmGlc6P 12.0
HXKgHXKgKeq 759.0
HXKgHXKgKmADP 0.126
HXKgHXKgKmATP 0.116
HXKgHXKgKmGlc 0.1
HXKgHXKgKmGlc6P 12.0
HXKgHXKgVmax 1929.0
O2c 1.0
PFKcPFKcVmax 0.1708
PFKcPFKgKeq 1035.0
PFKcPFKgKi1 15.8
PFKcPFKgKi2 10.7
PFKcPFKgKmADP 1.0
PFKcPFKgKmATP 0.0648
PFKcPFKgKmFru6P 0.999
PFKcPFKgKsATP 0.0393
PFKgPFKgKeq 1035.0
PFKgPFKgKi1 15.8
PFKgPFKgKi2 10.7
PFKgPFKgKmADP 1.0
PFKgPFKgKmATP 0.0648
PFKgPFKgKmFru6P 0.999
PFKgPFKgKsATP 0.0393
PFKgPFKgVmax 1708.0
PGA3TgPGA3Tgk 250.0
PGAMcPGAMcKeq 0.17
PGAMcPGAMcKmPGA2 0.16
PGAMcPGAMcKmPGA3 0.15
PGAMcPGAMcVmax 225.0
PGIcPGIcVmax 0.1305
PGIcPGIgKeq 0.46
PGIcPGIgKmFru6P 0.12
PGIcPGIgKmGlc6P 0.4
PGIgPGIgKeq 0.46
PGIgPGIgKmFru6P 0.12
PGIgPGIgKmGlc6P 0.4
PGIgPGIgVmax 1305.0
PGKcPGKcVmax 0.0286
PGKcPGKgKeq 3376.0
PGKcPGKgKmADP 0.1
PGKcPGKgKmATP 0.29
PGKcPGKgKmBPGA13 0.003
PGKcPGKgKmPGA3 1.62
PGKgPGKgKeq 3376.0
PGKgPGKgKmADP 0.1
PGKgPGKgKmATP 0.29
PGKgPGKgKmBPGA13 0.003
PGKgPGKgKmPGA3 1.62
PGKgPGKgVmax 2862.0
PYKcPYKcKeq 10800.0
PYKcPYKcKiADP 0.64
PYKcPYKcKiATP 0.57
PYKcPYKcKmADP 0.114
PYKcPYKcKmATP 15.0
PYKcPYKcKmPEP 0.34
PYKcPYKcKmPyr 50.0
PYKcPYKcVmax 1020.0
PYKcPYKcn 2.5
PyrTcPyrTcKmPyr 1.96
PyrTcPyrTcVmax 230.0
SHAM 0.0
TPIcTPIcVmax 0.09993
TPIcTPIgKeq 0.046
TPIcTPIgKmDHAP 1.2
TPIcTPIgKmGA3P 0.25
TPIgTPIgKeq 0.046
TPIgTPIgKmDHAP 1.2
TPIgTPIgKmGA3P 0.25
TPIgTPIgVmax 999.3
cytosol 5.4549
default 1.0
glycosome 0.2451

Local parameters

Id Value Reaction

Assignment rules

Definition

Rate rules

Definition

Algebraic rules

Definition
Trigger Assignments