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A detailed history of the nomenclature since the 1950s can be found [here](https://iubmb.qmul.ac.uk/enzyme/history.html).\n\nThere are few notable resources providing access to the Enzyme Nomenclature:\n\n<table class=\"table table-striped\"><thead><tr><th>Website</th><th>Homepage</td><th>Notes</td></tr></thead><tbody><tr><td>ExplorEnz</td><td><a href=\"https://www.enzyme-database.org\">https://www.enzyme-database.org</a></td><td>This is the resource officially recommended by IUBMB</td></tr><tr><td>IUBMB (via by Queen Mary)</td><td><a href=\"https://iubmb.qmul.ac.uk/enzyme\">https://iubmb.qmul.ac.uk/enzyme</a></td><td>This is a web-based version of the <a href=\"https://archive.org/details/enzymenomenclatu0000inte_d6c2\">1992 publication</a>.</td></tr><tr><td>IntEnz</td><td><a href=\"https://www.ebi.ac.uk/intenz\">https://www.ebi.ac.uk/intenz</a></td><td>Shutdown in 2024</td></tr><tr><td>ExPaSy</td><td><a href=\"https://enzyme.expasy.org\">https://enzyme.expasy.org</a></td></tr><tr><td>EnzymePortal</td><td><a href=\"https://www.ebi.ac.uk/enzymeportal\">https://www.ebi.ac.uk/enzymeportal</a></td><td></td></tr></tbody></table> Licensed under CC-BY-4.0.","extras":{"version.iri":"https://w3id.org/biopragmatics/resources/ec/2025-04-09/ec.ofn"},"homepage":"https://www.enzyme-database.org/","name":"Enzyme Nomenclature","prefix":"ec","uri_format":"https://www.enzyme-database.org/query.php?ec=$1"},"aberowl":null,"ncbi":null,"uniprot":{"homepage":"https://enzyme.expasy.org/","keywords":["Enzyme and pathway databases"],"name":"Enzyme nomenclature database","prefix":"DB-0024","publications":[{"doi":"10.1093/nar/28.1.304","pubmed":"10592255"}],"short_names":["ENZYME"],"uri_format":"https://enzyme.expasy.org/EC/$1"},"biolink":null,"cellosaurus":null,"ontobee":null,"cheminf":null,"fairsharing":{"description":"In its report in 1961, the first Enzyme Commission devised a system for enzyme classification that also serves as a basis for assigning code numbers. 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Therefore, SAREF4EHAW modular ontology shall both:\n - Allow the implementation of a limited set of typical EHAW related use cases already identified in ETSI TR 103 509, i.e.\n - Use case 1 ?elderly at home monitoring and support?,\n - Use case 2 ?monitoring and support of healthy lifestyles for citizens?,\n - Use case 3 ?Early Warning System (EWS) and Cardiovascular Accidents detection?.\n - Fulfil the eHealth Ageing Well related requirements provided in ETSI TR 103 509, mainly the ontological ones that were mostly taken as input for the ontology specification.\n\nSAREF4EHAW mainly reuses the following existing ontologies: SAREF, ETSI SmartBAN reference model, SAREF 4 Environment extension and W3C SSN System module. The following figure presents the high level view of SAREF4EHAW ontology.\n![SAREF4SYST overview](diagrams/SAREF4EHAW_Model.jpg)\nFor semantic interoperability handling purposes, an ontology based solution, combined with sensing-as-a-service and WoT strategies, is retained for SAREF4EHAW. Therefore, an upper level ontology, at service level, shall also behas been fully modelled (Service class and sub-classes depicted in the previous figure).\nFor embedded semantic analytics purposes, SAREF4EHAW shall behas been designed using the modularity principle (see ETSI TR 103 509) and can thus be mainly described by the following self-contained knowledge sub-ontologies (or modules): HealthActor, Ban, HealthDevice, Function (measured data related concepts included) and Service.","homepage":"https://saref.etsi.org/saref4ehaw/","keywords":["IoT"],"name":"SAREF4EHAW: an extension of SAREF for eHealth Ageing Well domain","prefix":"s4ehaw","uri_format":"https://saref.etsi.org/saref4ehaw/$1"},"zazuko":null,"togoid":null,"integbio":null,"pathguide":null,"tib":{"description":"SAREF4EHAW extension has been specified and formalised by investigating EHAW domain related resources","extras":{"version.iri":"https://saref.etsi.org/saref4ehaw/v2.1.1/"},"homepage":"https://saref.etsi.org/saref4ehaw/","keywords":["NFDI4ING","engineering"],"name":"SAREF4EHAW: an extension of SAREF for eHealth Ageing Well domain","prefix":"s4ehaw","tracker":"https://saref.etsi.org/sources/saref4ehaw/issues","uri_format":"https://saref.etsi.org/saref4ehaw/$1"}},"saref.ener":{"prefix":"saref.ener","name":null,"description":null,"pattern":null,"uri_format":null,"uri_format_resolvable":null,"rdf_uri_format":null,"providers":null,"homepage":null,"repository":null,"contact":null,"contact_extras":null,"contact_group_email":null,"contact_page":null,"owners":null,"example":"ActuatorLevel","example_extras":null,"example_decoys":null,"license":null,"version":null,"part_of":null,"part_of_database":null,"provides":null,"download_owl":null,"download_obo":null,"download_json":null,"download_rdf":null,"download_skos":null,"download_jskos":null,"banana":null,"banana_peel":null,"deprecated":null,"mappings":{"lov":"s4ener","tib":"s4ener"},"synonyms":["s4ener"],"keywords":null,"domain":null,"references":null,"publications":null,"appears_in":null,"depends_on":null,"namespace_in_lui":null,"no_own_terms":null,"comment":null,"contributor":null,"contributor_extras":null,"reviewer":null,"reviewer_extras":null,"proprietary":null,"has_canonical":null,"preferred_prefix":null,"mastodon":null,"github_request_issue":null,"logo":null,"miriam":null,"n2t":null,"prefixcommons":null,"wikidata":null,"wikidata_entity":null,"go":null,"obofoundry":null,"bioportal":null,"ecoportal":null,"agroportal":null,"cropoct":null,"ols":null,"aberowl":null,"ncbi":null,"uniprot":null,"biolink":null,"cellosaurus":null,"ontobee":null,"cheminf":null,"fairsharing":null,"biocontext":null,"edam":null,"re3data":null,"hl7":null,"bartoc":null,"rrid":null,"lov":{"description":"This is the extension of SAREF for the EEBus and Energy@Home project. The documentation of SAREF4EE is available at http://ontology.tno.nl/SAREF4EE_Documentation_v0.1.pdf. SAREF4EE represents 1) The configuration information exchanged in the use case 'Remote Network Management' according to the EEBus Technical Report, Protocol Specification- Remote Network Management, version 1.0.0.2, 2015-09-19; 2) The scheduling information about power sequences exchanged in the use cases Appliance scheduling through CEM and remote start' and 'Automatic cycle rescheduling', according to the message structures described in General Message Structures, version 0.1.1, 2015-10-07; 3) The monitor and control information exchanged in the use case 'Communicate appliance status and info on manually planned cycles', according to the monitoring and control part of the Energy@Home Data Model, version 1.0; and 4) the event-based data exchanged in the use case 'Demand Response', according to General Message Structures, version 0.1.1, 2015-10-07.","homepage":"https://saref.etsi.org/saref4ener/","keywords":["Environment","Services"],"name":"SAREF4EE: the EEbus/Energy@home extension of SAREF","prefix":"s4ener","uri_format":"https://saref.etsi.org/saref4ener/$1"},"zazuko":null,"togoid":null,"integbio":null,"pathguide":null,"tib":{"description":"SAREF4ENER is an extension of SAREF for the Energy domain that was created in collaboration with Energy@Home (http://www.energy-home.it) and EEBus (http://www.eebus.org/en), the major Italy- and Germany-based industry associations, to enable the interconnection of their (different) data models. SAREF4ENER focuses on demand response scenarios, in which customers can offer flexibility to the Smart Grid to manage their smart home devices by means of a Customer Energy Manager (CEM). The CEM is a logical function for optimizing energy consumption and/or production that can reside either in the home gateway or in the cloud. SAREF4ENER is published as an ETSI tecnical specificatoion (ETSI TS 103 410-1).","extras":{"version.iri":"https://saref.etsi.org/saref4ener/v2.1.1/"},"homepage":"https://saref.etsi.org/saref4ener/","keywords":["NFDI4ING","NFDI4Energy","Digital Planning and Construction","FID BAUdigital","engineering"],"name":"SAREF for Energy 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is an extension of SAREF for the industry and manufacturing domain. SAREF4INMA focuses on extending SAREF for the industry and manufacturing domain to solve the lack of interoperability between various types of production equipment that produce items in a factory and, once outside the factory, between different organizations in the value chain to uniquely track back the produced items to the corresponding production equipment, batches, material and precise time in which they were manufactured. SAREF4INMA is specified and published by ETSI in the TS 103 410-5 associated to this ontology file. SAREF4INMA was created to be aligned with related initiatives in the smart industry and manufacturing domain in terms of modelling and standardization, such as the Reference Architecture Model for Industry 4.0 (RAMI), which combines several standards used by the various national initiatives in Europe that support digitalization in manufacturing. The full list of use cases, standards and requirements that guided the creation of SAREF4INMA are described in the associated ETSI TR 103 507.","homepage":"https://saref.etsi.org/saref4inma/","keywords":["Industry","IoT"],"name":"SAREF4INMA: an extension of SAREF for the industry and manufacturing domain","prefix":"s4inma","uri_format":"https://saref.etsi.org/saref4inma/$1"},"zazuko":null,"togoid":null,"integbio":null,"pathguide":null,"tib":{"description":"SAREF4INMA is an extension of SAREF for the industry and manufacturing domain. SAREF4INMA focuses on extending SAREF for the industry and manufacturing domain to solve the lack of interoperability between various types of production equipment that produce items in a factory and, once outside the factory, between different organizations in the value chain to uniquely track back the produced items to the corresponding production equipment, batches, material and precise time in which they were manufactured. SAREF4INMA is specified and published by ETSI in the TS 103 410-5 associated to this ontology file. SAREF4INMA was created to be aligned with related initiatives in the smart industry and manufacturing domain in terms of modelling and standardization, such as the Reference Architecture Model for Industry 4.0 (RAMI), which combines several standards used by the various national initiatives in Europe that support digitalization in manufacturing. The full list of use cases, standards and requirements that guided the creation of SAREF4INMA are described in the associated ETSI TR 103 507.","extras":{"version.iri":"https://saref.etsi.org/saref4inma/v2.1.1/"},"homepage":"https://saref.etsi.org/saref4inma/","keywords":["NFDI4ING","engineering"],"name":"SAREF4INMA: an extension of SAREF for the industry and manufacturing 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present document is the technical specification of SAREF4SYST, a generic extension of [ETSI TS 103 264 SAREF](https://www.etsi.org/deliver/etsi_ts/103200_103299/103264/02.01.01_60/ts_103264v020101p.pdf) that defines an ontology pattern which can be instantiated for different domains. SAREF4SYST defines Systems, Connections between systems, and Connection Points at which systems may be connected. These core concepts can be used generically to define the topology of features of interest, and can be specialized for multiple domains. The topology of features of interest is highly important in many use cases. If a room holds a lighting device, and if it is adjacent with an open window to a room whose luminosity is low, then by turning on the lighting device in the former room one may expect that the luminosity in the latter room will rise.\n\nThe SAREF4SYST ontology pattern can be instantiated for different domains. For example to describe zones inside a building (systems), that share a frontier (connections). Properties of systems are typically state variables (e.g. agent population, temperature), whereas properties of connections are typically flows (e.g. heat flow).\n\nSAREF4SYST has two main aims: on the one hand, to extend SAREF with the capability or representing general topology of systems and how they are connected or interact and, on the other hand, to exemplify how ontology patterns may help to ensure an homogeneous structure of the overall SAREF ontology and speed up the development of extensions.\n\nSAREF4SYST consists both of a core ontology, and guidelines to create ontologies following the SAREF4SYST ontology pattern. The core ontology is a lightweight OWL-DL ontology that defines 3 classes and 9 object properties.\n\nUse cases for ontology patterns are described extensively in  [ETSI TR 103 549 Clauses 4.2 and 4.3](https://www.etsi.org/deliver/etsi_tr/103500_103599/103549/01.01.01_60/tr_103549v010101p.pdf).\n\nFor the Smart Energy domain:\n\n- Electric power systems can exchange electricity with other electric power systems. The electric energy can flow both ways in some cases (from the Public Grid to a Prosumer), or in only one way (from the Public Grid to a Load). Electric power systems can be made up of different sub-systems. Generic sub-types of electric power systems include producers, consumers, storage systems, transmission systems. \n- Electric power systems may be connected one to another through electrical connection points. An Electric power system may have multiple connection points (Multiple Winding Transformer generally have one single primary winding with two or more secondary windings). Generic sub-types of electrical connection points include plugs, sockets, direct-current, single-phase, three-phase, connection points. \n- An Electrical connection may exist between two Electric power systems at two of their respective connection points. Generic sub-types of electrical connections include Single-phase Buses, Three-phase Buses. A single-phase electric power system can be connected using different configurations at a three-phase bus (RN, SN, TN types).\n\nFor the Smart Building domain:\n\n- Buildings, Storeys, Spaces, are different sub-types of Zones. Zones can contain sub-zones. Zones can be adjacent or intersect with other zones. \n- Two zones may share one or more connections. 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In particular the following ones have been considered in the project:\n- [Freesound](https://freesound.org/), a collaborative database of Creative Commons Licensed sounds;\n- [Jamendo](https://www.jamendo.com/), a music website for independent artists;\n- [Europeana Sounds](https://www.eusounds.eu/), a European project collecting and sharing data from several archives of sounds and sound-related media;\n- [Internet Archive](https://archive.org/), a non-profit library of millions of freely accessible media contents.\n\n### The base model\n<center> ![A diagram showing the entities Work, Expression, Manifestation, Item](./img/FRBR-Group-1-entities-and-basic-relations.svg.png) </center>\nThe Audio Commons ontology is based on [Functional Requirements for Bibliographic Records (FRBR)](https://en.wikipedia.org/wiki/Functional_Requirements_for_Bibliographic_Records), a bibliographic model designed for user tasks of retrieval and access in online library catalogues and bibliographic databases. FRBR distinguish the products of intellectual or artistic endeavor in four main classes: work, expression, manifestation, item. It is available as RDF vocabulary at https://vocab.org/frbr/core. For further information on FRBR, check the [standard](https://repository.ifla.org/handle/123456789/811).\n\nAnother important model related to audio is the [Music Ontology](http://musicontology.com/), which is also based on the FRBR model. Our ontology is more generic than the Music Ontology but is interoperable with it to support the specificities of music-related audio content.\n\nThe Audio Commons ontology works also in conjunction with\n- [Dublin Core](https://www.dublincore.org/specifications/dublin-core/dcmi-terms/) for basic metadata,\n- [EBU Core](https://www.ebu.ch/metadata/ontologies/ebucore/) for technical properties of audio files,\n- [SKOS](https://www.w3.org/TR/skos-primer/) to support taxonomic classifications,\n- [Creative Commons Licensing schema](https://creativecommons.org/ns) to represent media licensing,\n- [Event ontology](http://motools.sf.net/event/event.html) for the formalisation of events,\n- [Audio Features Ontology](https://w3id.org/afo/onto/) for the characterisation of audio features.\n\n### Ontology overview\n\n![A diagram showing the main classes of the Audio Commons ontology](./img/AC-Ontology-Skeleton.png)\n\nThe figure above shows the most general classes and properties of the Audio Commons ontology and their relationship with classes of the FRBR and the Music Ontology:\n- **`ac:AudioExpression`**, the specific intellectual or artistic form that a work takes each time it is _realised_, in the audio domain, e.g., the recording or synthesis of music or sounds;\n- **`ac:AudioManifestation`**, the physical embodiment of an audio expression, e.g., a musical track, a sound, an album; \n- **`ac:AudioItem`**, a single exemplar of an audio manifestation, e.g., a copy of a CD or a specific media file.\n\nThe FRBR class Work, representing a distinct intellectual or artistic creation on a more conceptual level, has not been specialised in Audio Commons.\n\nThe Audio Commons ontology provides a generic schema for audio classification through the property **`ac:audioCategory`** that associates any audio expression, manifestation, or item to some generic **`ac:AudioCategory`**. These two terms can be specialised to provide spefic categorisations.\n\n### Manifestations: audio clips and collections\n\n![A diagram showing the main classes of the Audio Commons ontology](./img/AC-Ontology-Manifestation.png)\n\nThe figure above shows classes and properties related to audio manifestations. An instance of **`ac:AudioClip`**, a subclass of `ac:AudioManifestation`, is any audio segment that has been published in some form or uploaded for consumption, for example, a track in a music label's repository or a sound in an audio repository, library or archive.\n\nThe class **`ac:AudioCollection`**, another subclass of `ac:AudioManifestation`, is used to represent collections of audio clips. The class **`ac:AudioCollectionNode`** is used to represent single nodes of a collection, offering local information like the index in the collection and pointers to previous and next nodes. The separation between the collection node and its actual content (e.g., an `ac:AudioClip`) permits the same content to be shared in multiple collections.\n\nThe content of each node of a collection is not limited to an `ac:AudioClip`, but may contain any `ac:AudioManifestation`. Collections can thus contain other collections to support specific cases, e.g. a mapping to the Music Ontology model where an `mo:Release` can contain multiple `mo:Record`(s) that can in turn contain multiple `mo:Track`(s).\n### Items: audio files\n![A diagram showing ac:Item class and related class and properties](./img/AC-Ontology-Item.png)\n\nAn `ac:AudioItem` is a concrete exemplar of an audio manifestation. In our domain, the main exemplars are the actual audio files. \n\nThe corresponding class **`ac:AudioFile`** is a subclass of `ac:AudioItem`. It is subclass of `ebu:MediaResource` too and the corresponging properties of EBU Core can be used to describe the file (e.g., `ebu:hasEncodingFormat`, `ebu:fileSize`).\n\n### Expressions: audio signals\n![A diagram showing ac:Expression class and related class and properties](./img/AC-Ontology-Expression.png)\n\nWhile `ac:AudioFile` represents a concrete file encoded in a certain format, **`ac:DigitalSignal`** is the representation of the corresponding digital signal. `ac:DigitalSignal` is a subclass of `ac:MusicalExpression`. \n\nThe data properties `ac:sampleRate`, `ac:bitsPerSample`, and `ac:channels`, associate a signal with its basic features specific to digital representations.\n\nThe property `ac:publicationOf` can be used to associate an `ac:AudioClip` with the corresponding digital signal. 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